Analytical method development

Name: Analytical method development
Brand: LAP Lambert Academic Publishing
SKU: 9783846528662
Price: 967 CZK
Availability: InStock

Analytical and Bioanalytical Method Development of Amlodipine Besylate and Enalapril Maleate and its Formulation

Autor: Pournima Patil, Harinath More, Sachin Pishwikar

Jazyk:

Vazba: Brožovaná

Vydavatel: LAP Lambert Academic Publishing

Dostupnost: Skladem u dodavatele

Odesíláme za 5-8 dnů

967 Kč

Combination of drugs is often formulated to increase the potency of the dosage form and to decrease...

Informace o knize

Autor

Pournima Patil, Harinath More, Sachin Pishwikar

Jazyk

Angličtina

Vazba

Kniha - Brožovaná

Vydáno

2011

Stránek

EAN

9783846528662

Enbook ID

07045588

Vydavatel

LAP Lambert Academic Publishing

Hmotnost

159

Rozměry

150 x 220 x 6

Kompletní popis

Combination of drugs is often formulated to increase the potency of the dosage form and to decrease the number of tablets taken for the management of diseases. In present work, methods of simultaneous estimation of Olmesartan Medoxomil and Amlodipine besylate in their combined dosage form are developed, as literature survey revealed that no method for simultaneous estimation of these drugs is reported. After studying the stability of both the drugs in methanol and acetonitrile, Olmesartan shows poor stability in methanol whereas in acetonitrile it shows good stability therefore acetonitrile is used for method development. Bioanalytical method validation was done by USFDA guidelines. Bioanalytical method validation was done by USFDA guidelines. Recoveries in all these method were in the range of 98-101%. Results obtained were statistically validated and were found to be reproducible. These methods can be applied for routine analysis of formulations containing these drugs. For analytical methods validation parameters such as linearity, precision, accuracy, specificity, limit of detection, limit of quantitation and robustness were determined according to ICH Q2B guidelines.

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Analytical method development

Analytical and Bioanalytical Method Development of Amlodipine Besylate and Enalapril Maleate and its Formulation

Informace o knize

Kompletní popis

Mohlo by vás zajímat

Zákaznicí kteří koupili tuto knihu koupili také