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Kniha Applied Pharmacometrics Hartmut Derendorf

Applied Pharmacometrics

Autor: Hartmut Derendorf, Stephan Schmidt
Jazyk: Angličtina
Vazba: Brožovaná
Vydavatel: Springer-Verlag New York Inc.
Dostupnost: Skladem u dodavatele
Odesíláme za 10-18 dnů
5 860 Kč
This comprehensive volume provides an update on the current state of pharmacometrics in drug develop...

Informace o knize

Autor
Hartmut Derendorf, Stephan Schmidt
Jazyk
Angličtina
Vazba
Kniha - Brožovaná
Vydáno
2016
Stránek
565
EAN
9781493946167
ISBN
1493946161
Enbook ID
14203430
Vydavatel
Springer-Verlag New York Inc.
Hmotnost
8657
Rozměry
155 x 235 x 32

Kompletní popis

This comprehensive volume provides an update on the current state of pharmacometrics in drug development. It consists of nineteen chapters all written by leading scientists from the pharmaceutical industry, regulatory agencies and academia. After an introduction of the basic pharmacokinetic and pharmacodynamic concepts of pharmacometrics in drug development, the book presents numerous examples of specific applications that utilize pharmacometrics with modeling and simulations over a variety of therapeutic areas, including pediatrics, diabetes, obesity, infections, psychiatrics, Alzheimer's disease, and dermatology, among others. The examples illustrate how results from all phases of drug development can be integrated in a more timely and cost-effective process. Applying pharmacometric decision tools during drug development can allow objective, data-based decision making. At the same time, the process can identify redundant or unnecessary experiments as well as some costly clinical trials that can be avoided. In addition to cost saving by expedited development of successful drug candidates, pharmacometrics has an important economic impact in drug product selection. Unsuccessful drug candidates can be identified early and discontinued without expending efforts required for additional studies and allocating limited resources. Hence, pharmacometric modeling and simulation has become a powerful tool to bring new and better medications to the patient at a faster pace and with greater probability of success.

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