Kniha Cold Thermal Processing in the Spinal Cord Paul Wrigley

Cold Thermal Processing in the Spinal Cord

In Search of Therapeutic Targets for Cold Hyperesthesia

Autor: Paul Wrigley
Jazyk: Angličtina
Vazba: Brožovaná
Dostupnost: U nakladatele na objednávku
Odesíláme za 17-27 dnů
1 618
Two recently identified transient receptor potential (TRP) channels, TRPM8 and TRPA1, have been prop...

Informace o knize

Autor
Jazyk
Angličtina
Vazba
Kniha - Brožovaná
Vydáno
2010
Stránek
180
EAN
9783639103434
Enbook ID
06819328
Hmotnost
284
Rozměry
150 x 220 x 11

Kompletní popis

Two recently identified transient receptor potential (TRP) channels, TRPM8 and TRPA1, have been proposed to play an important role in mammalian cool and cold peripheral sensory transduction. When expressed in cell-lines the cloned TRPM8 and TRPA1 receptors have distinct pharmacological and temperature response characteristics. Although these receptors are also transported to the central terminals of primary afferents, little is known about their centrally mediated actions. In this thesis an in vitro electrophysiological approach is used to investigate the dorsal horn processing of cool afferent modalities and the role of TRP ion channels. The results of this thesis provide further information on thermal processing, indicate direction for further research and suggest possible therapeutic targets for the management of abnormal cold sensory processing.

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