Computational Methods for Fragment Spectrum Interpretation

Name: Computational Methods for Fragment Spectrum Interpretation
Brand: VDM Verlag
SKU: 9783639228588
Price: 1149 CZK
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Computational Interpretation of Tandem MS Spectra Including Fragment Ions with Post-Translational Modifications

Autor: Jonathan Rameseder, Lennart Martens

Jazyk:

Vazba: Brožovaná

Vydavatel: VDM Verlag

Dostupnost: Skladem u dodavatele

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Post-translational modifications (PTMs) are of critical importance for a vast range of cellular proc...

Informace o knize

Autor

Jonathan Rameseder, Lennart Martens

Jazyk

Angličtina

Vazba

Kniha - Brožovaná

Vydáno

2010

Stránek

EAN

9783639228588

ISBN

3639228588

Enbook ID

06830633

Vydavatel

VDM Verlag

Hmotnost

Rozměry

152 x 229 x 10

Kompletní popis

Post-translational modifications (PTMs) are of critical importance for a vast range of cellular processes such as growth control and signal transduction. Mass spectrometry (MS) can shed light on the characteristics of PTMs to gain insight into the mechanisms of numerous diseases including cancer. However, interpretation of tandem MS spectra including fragment ions with PTMs from high-throughput experiments is a complex challenge. The high number and diversity of known PTMs as well as suboptimal quality of spectra compromise the identification of PTMs in MS experiments. In this book, an efficient algorithm for the computational interpretation of tandem MS spectra including fragment ions with PTMs is described. Information on both precursor and fragment ion level is utilized and an arbitrary number of PTMs is considered. A robust statistical noise intensity model is developed to compensate for low spectrum quality. Finally, the algorithm is successfully applied on the fragment spectra in the PRIDE proteomics data repository to render it suitable for statistical machine learning investigations.

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Computational Methods for Fragment Spectrum Interpretation

Computational Interpretation of Tandem MS Spectra Including Fragment Ions with Post-Translational Modifications

Informace o knize

Kompletní popis

Mohlo by vás zajímat

Zákaznicí kteří koupili tuto knihu koupili také