Kniha Filaggrin Jacob P. Thyssen

Filaggrin

Basic Science, Epidemiology, Clinical Aspects and Management

Jazyk: Angličtina
Vazba: Pevná
Dostupnost: Skladem u dodavatele
Odesíláme za 9-15 dnů
2 595
Filaggrin gene mutations are common in Europeans and their descendants, as well as in Asians, reachi...

Informace o knize

Jazyk
Angličtina
Vazba
Kniha - Pevná
Vydáno
2014
Stránek
373
EAN
9783642543784
ISBN
3642543782
Enbook ID
02433234
Hmotnost
1012
Rozměry
180 x 261 x 22

Kompletní popis

Filaggrin gene mutations are common in Europeans and their descendants, as well as in Asians, reaching a prevalence of up to 10%. Filaggrin proteins are crucial for skin homeostasis as their metabolites maintain skin hydration, keep the skin pH low, and provide protection against solar radiation. FLG mutation carriers suffer from dry and scaly skin and have an increased transfer of allergens and chemicals across the epidermis. Moreover, they have 10% higher serum vitamin D levels, potentially affecting the propensity to develop other diseases. FLG loss-of-function mutations represent the strongest risk factor hitherto discovered for atopic dermatitis and are major predisposing factors for related asthma and hay fever. This textbook provides comprehensive and detailed coverage of the effects of FLG mutations in health and disease (cutaneous and non-cutaneous) and also discusses the basic science, epidemiology, management, and future research areas.

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