Kniha Genetic algorithm for haplotyping and block partitioning Nadezhda Sazonova

Genetic algorithm for haplotyping and block partitioning

Jazyk: Angličtina
Vazba: Brožovaná
Vydavatel: VDM Verlag
Dostupnost: U nakladatele na objednávku
Odesíláme za 17-27 dnů
1 407
A new algorithm for performing simultaneous haplotype resolution and block partitioning is proposed....

Informace o knize

Jazyk
Angličtina
Vazba
Kniha - Brožovaná
Vydáno
2010
Stránek
132
EAN
9783639237849
ISBN
3639237846
Enbook ID
06831469
Vydavatel
Hmotnost
204
Rozměry
152 x 229 x 8

Kompletní popis

A new algorithm for performing simultaneous haplotype resolution and block partitioning is proposed. The algorithm is based on genetic algorithm approach and the parsimonious principle. The multiloculs LD measure (Normalized Entropy Difference) is used as a block identification criterion. The proposed algorithm incorporates missing data is a part of the model and allows blocks of arbitrary length. In addition, the algorithm provides scores for the block boundaries which represent measures of strength of the boundaries at specific positions. The results show that the proposed genetic algorithm provides the accuracy of haplotype decomposition within the range of the same indicators shown by the other algorithms. The proposed algorithm is also used in a new population clustering algorithm, which extracts from the given genotype sample two clusters with substantially different block structures and finds haplotype resolution and block partitioning for each cluster.

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