Genome - Kinome

Name: Genome - Kinome
Brand: VDM Verlag Dr. Müller
SKU: 9783639137774
Price: 1407 CZK
Availability: InStock

Utilize cross species genomic information to develop a species specific tool for global kinome analysis

Autor: Shakiba Jalal

Jazyk:

Vazba: Brožovaná

Vydavatel: VDM Verlag Dr. Müller

Dostupnost: U nakladatele na objednávku

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Kinases belong to one of the most biologically§significant enzyme classes. The development of§analyt...

Informace o knize

Autor

Shakiba Jalal

Jazyk

Angličtina

Vazba

Kniha - Brožovaná

Vydáno

2009

Stránek

132

EAN

9783639137774

Enbook ID

06822438

Vydavatel

VDM Verlag Dr. Müller

Rozměry

220

Kompletní popis

Kinases belong to one of the most biologically§significant enzyme classes. The development of§analytical techniques for characterization of kinase§activity, in particular at a global scale, is a§central priority for proteomic and cell biology§researchers.§In order to facilitate global analysis of cellular§phosphorylation, a new paradigm of microarray§technology which focuses on analysis of total§cellular kinase activity, kinome, has emerged in the§past few years.§As the specificity of many kinases is dictated§primarily by recognition of residues immediately§surrounding the site of phosphorylation a logical§methodology is to employ peptides§representing these immediate sequences as§experimental substrates. Microarray chips carrying§hundreds of such substrate targets have been§developed for human kinome analysis, however,§lack of similar tools for species outside research§mainstream has limited kinome analysis in§these species. This work describes a methodology to§create species specific peptide arrays. A case study§is carried out to analyze Toll Like Receptor (TLR)§signaling pathways in bovine monocytes.

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Genome - Kinome

Utilize cross species genomic information to develop a species specific tool for global kinome analysis

Informace o knize

Kompletní popis

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