Kniha Intelligent Disulfide Connectivity Discovery Monther Alhamdoosh

Intelligent Disulfide Connectivity Discovery

Towards Protein 3D Structure Prediction

Jazyk: Angličtina
Vazba: Brožovaná
Dostupnost: Skladem u dodavatele
Odesíláme za 5-8 dnů
967
The disulfide connectivity of a protein chain containing oxidized cysteines determines the pairing m...

Informace o knize

Jazyk
Angličtina
Vazba
Kniha - Brožovaná
Vydáno
2013
Stránek
120
EAN
9783659200793
Enbook ID
02208262
Hmotnost
197
Rozměry
150 x 220 x 7

Kompletní popis

The disulfide connectivity of a protein chain containing oxidized cysteines determines the pairing motif of these cysteines. This book aims at developing an intelligent system to predict the disulfide connectivity from solely the protein primary sequence. The book examines two different machine learning approaches to develop such systems: Neural Networks and Support Vector Machines. The book flows in five chapters that introduce the problem of disulfide connectivity prediction, thoroughly review the state-of-the-art researches, present our two-phase machine learning framework and technical details, and eventually investigate the performance of this intelligent system on real data from PDB database. This book, therefore, is step-by-step guide for researchers to develop intelligent systems that facilitate discovering disulfide connectivity patterns in protein chains. Moreover, researchers interested in the challenging problem of protein 3D structure prediction can benefit from this book to reduce the number of possible structural conformations of a given protein sequence and consequently obtain better understanding of protein folding.

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