Interactions between membrane transporters and phospholipids

Name: Interactions between membrane transporters and phospholipids
Brand: VDM Verlag
SKU: 9783639136708
Price: 1172 CZK
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Autor: Pierre Hakizimana

Jazyk:

Vazba: Brožovaná

Vydavatel: VDM Verlag

Dostupnost: U nakladatele na objednávku

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1 172 Kč

Highly solved crystal structures and a wealth of§biochemical data are now available for an increasin...

Informace o knize

Autor

Pierre Hakizimana

Jazyk

Angličtina

Vazba

Kniha - Brožovaná

Vydáno

2009

Stránek

EAN

9783639136708

ISBN

3639136705

Enbook ID

06822344

Vydavatel

VDM Verlag

Hmotnost

145

Rozměry

152 x 229 x 6

Kompletní popis

Highly solved crystal structures and a wealth of§biochemical data are now available for an increasing§number of membrane proteins. However, the question of§how lipid molecules interact with integral membrane§proteins and regulate their structure and function in§biological membranes remains unsatisfactorily addressed. §This book discusses the functional mechanisms§of membrane proteins in general and the effect of the§surrounding lipidic environment, in the context of§recent developments in the field. Recent experimental§investigations on the proton gradient-driven§multidrug transporter LmrP are also discussed. Using§this membrane protein as a model, we demonstrated§that the protein structure and function was depending§on the phosphatidylethanolamine (PE) headgroup. We§then showed that a negatively charged residue, Asp68,§could participate in the interaction with PE and that§such interaction is required for proper activity and§structure of the protein. Because Asp-68 belongs to a§highly conserved motif of the Major Facilitator§Superfamily (MFS) , this interaction might be a§general feature of these transporters that is§involved in proton gradient sensing and lipid dependence.

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Interactions between membrane transporters and phospholipids

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