Lead Exposure

Name: Lead Exposure
Brand: VDM Verlag Dr. Müller
SKU: 9783639147957
Price: 1875 CZK
Availability: InStock

Global and Quantitative Gene Expression Analysis of the Effects of Drinking Water Exposure to Lead Acetate in Fisher 344 Male Rats Liver

Autor: Worlanyo Gato

Jazyk:

Vazba: Brožovaná

Vydavatel: VDM Verlag Dr. Müller

Dostupnost: U nakladatele na objednávku

Odesíláme za 17-27 dnů

1 875 Kč

The primary objective of this work was to analyze §global gene expression patterns occurring in Fish...

Informace o knize

Autor

Worlanyo Gato

Jazyk

Angličtina

Vazba

Kniha - Brožovaná

Vydáno

2009

Stránek

276

EAN

9783639147957

Enbook ID

06823360

Vydavatel

VDM Verlag Dr. Müller

Hmotnost

427

Rozměry

150 x 220 x 17

Kompletní popis

The primary objective of this work was to analyze §global gene expression patterns occurring in Fisher §344 rat livers exposed to varying levels of lead. §Results showed differentially expressed genes §including genes cited in the literature and several §not previously reported to be affected by lead §toxicity. Expression profiles were clustered and §gene ontology (GO) revealed 15 GO categories §affected by chronic (90d) exposure, while 3 GO §categories were affected during (30d) exposures. §Pathways emphasized the importance of Pb in §modulating various cellular events in a manner §similar to calcium regulation, including calcium §signaling phosphorylation and dephosphorylation, §histone acetylation and deacetylation. Conclusions §include: Pb controls mammalian protein synthesis via §regulating phosphorylation or dephosphorylation §events of eukaryotic elongation/initiation factors; §Pb regulates gene expression through the regulation §of histone acetylases and Pb regulates calcium §dependent transcription factor myocyte enhance §factor-2. Quantitative PCR was employed in §validating the microarray result and showed that §Microarrays and qRT-PCR yield comparable results.

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Lead Exposure

Global and Quantitative Gene Expression Analysis of the Effects of Drinking Water Exposure to Lead Acetate in Fisher 344 Male Rats Liver

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Kompletní popis

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