Melanotransferrin

Name: Melanotransferrin
Brand: VDM Verlag
SKU: 9783639140835
Price: 1875 CZK
Availability: InStock

Examination of the functional role of melanoma tumour antigen p97

Autor: Louise Dunn

Jazyk:

Vazba: Brožovaná

Vydavatel: VDM Verlag

Dostupnost: U nakladatele na objednávku

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Melanotransferrin (melanoma tumour antigen p97) is an§iron-§binding transferrin homologue expressed...

Informace o knize

Autor

Louise Dunn

Jazyk

Angličtina

Vazba

Kniha - Brožovaná

Vydáno

2009

Stránek

236

EAN

9783639140835

ISBN

3639140834

Enbook ID

06822717

Vydavatel

VDM Verlag

Hmotnost

349

Rozměry

152 x 229 x 14

Kompletní popis

Melanotransferrin (melanoma tumour antigen p97) is an§iron-§binding transferrin homologue expressed at high§levels on §melanoma tumours and at lower levels on normal§tissues. Unlike its §relatives, transferrin and lactoferrin,§melanotransferrin is §membrane-bound. These properties suggest that§melanotransferrin §may assist melanoma and other tumour cell types with§their increased requirement for iron. To address this§hypothesis we §utilised models including: (i) the melanotransferrin§knockout mouse, and (ii) systematic down-regulation of §melanotransferrin in melanoma cells using siRNA.§Rigorous §phenotypic§characterisation of this knockout mouse demonstrated no §differences in iron metabolism, behaviour or other§physiological parameters compared to wild-type§controls. In §melanoma cells, melanotransferrin was found to§facilitate §proliferation and §migration, and also to enhance tumourigenesis in nude§mice. §Moreover, whole genome array analysis of these models§in addition §to cell models of melanotransferrin over-expression§indicated §differences in genes associated with growth.

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Melanotransferrin

Examination of the functional role of melanoma tumour antigen p97

Informace o knize

Kompletní popis

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Zákaznicí kteří koupili tuto knihu koupili také