Microparticle Formation by Spray-Freeze-Drying

Name: Microparticle Formation by Spray-Freeze-Drying
Brand: Sudwestdeutscher Verlag Fur Hochschulschriften AG
SKU: 9783838117713
Price: 1571 CZK
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The Influence of Atomization Conditions on Protein Secondary and Tertiary Structure

Autor: Sebastian Vonhoff

Jazyk:

Vazba: Brožovaná

Vydavatel: Sudwestdeutscher Verlag Fur Hochschulschriften AG

Dostupnost: Skladem u dodavatele

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1 571 Kč

This thesis deals with the preparation microparticles by spray-freeze-drying (SFD). As the process c...

Informace o knize

Autor

Sebastian Vonhoff

Jazyk

Angličtina

Vazba

Kniha - Brožovaná

Vydáno

2010

Stránek

188

EAN

9783838117713

ISBN

3838117719

Enbook ID

07139440

Vydavatel

Sudwestdeutscher Verlag Fur Hochschulschriften AG

Hmotnost

281

Rozměry

152 x 229 x 12

Kompletní popis

This thesis deals with the preparation microparticles by spray-freeze-drying (SFD). As the process consists of various unit operations, the stability of labile APIs, such as proteins, can be serverly impaired. The secondary structure of a protein is known to be directly linked to its overall stability. However, quantification of protein secondary structure by FTIR spectroscopy can show poor reproducibility. Therefore, the first part of this thesis covers the development of a new FTIR method for objective and fast determination of protein secondary structure. The second part investigates the influence of atomization conditions on protein secondary and tertiary structure as well as residual enzyme activity during SFD. The process is analyzed after a) atomization b) atomization, freezing and thawing and c) the complete SFD process. A thorough comparison of the utilized ultrasound nozzles (including particle size distribution, temperatures and cavitation effects) is performed in the third part of this thesis. In the fourth and last part, different formulations containing a mixture of alpha-chymotrypsin and various excipients are evaluated for their stability.

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Microparticle Formation by Spray-Freeze-Drying

The Influence of Atomization Conditions on Protein Secondary and Tertiary Structure

Informace o knize

Kompletní popis

Mohlo by vás zajímat

Zákaznicí kteří koupili tuto knihu koupili také