Modelling Proteasome Dynamics in a Bayesian Framework

Name: Modelling Proteasome Dynamics in a Bayesian Framework
Brand: Springer Fachmedien Wiesbaden
SKU: 9783658201661
Price: 1310 CZK
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Autor: Sabine Stübler

Jazyk:

Vazba: Brožovaná

Vydavatel: Springer Fachmedien Wiesbaden

Dostupnost: Skladem u dodavatele v malém množství

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Sabine Stübler compares different proteasome isoforms and subtypes in terms of their transport and a...

Informace o knize

Autor

Sabine Stübler

Jazyk

Angličtina

Vazba

Kniha - Brožovaná

Vydáno

2017

Stránek

EAN

9783658201661

ISBN

3658201665

Enbook ID

18368854

Vydavatel

Springer Fachmedien Wiesbaden

Hmotnost

1557

Rozměry

148 x 210 x 6

Kompletní popis

Sabine Stübler compares different proteasome isoforms and subtypes in terms of their transport and active site-related parameters applying an existing computational model. In a second step, the author extends this model to be able to describe the influence of proteasome inhibitors in in vitro experiments. The computational model, which describes the hydrolysis of short fluorogenic peptides by the 20S proteasome, is calibrated to experimental data from different proteasome isoforms using an approximate Bayesian computation approach. The dynamics of proteasome inhibitors are included into the model in order to demonstrate how to modulate the inhibitor's transport parameters for strong or isoform-specific inhibition.

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Modelling Proteasome Dynamics in a Bayesian Framework

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