Molecular Dynamic Simulation Studies

Name: Molecular Dynamic Simulation Studies
Brand: SPS
SKU: 9783330650909
Price: 1768 CZK
Availability: InStock

Autor: Vijay Raj Bollapalli, V. Raghavendra Rao Morusupalli

Jazyk:

Vazba: Brožovaná

Vydavatel: SPS

Dostupnost: Skladem u dodavatele

Odesíláme za 5-8 dnů

1 768 Kč

Mdm2 has been identified as a p53 interacting protein towards represses p53 transcriptional activity...

Informace o knize

Autor

Vijay Raj Bollapalli, V. Raghavendra Rao Morusupalli

Jazyk

Angličtina

Vazba

Kniha - Brožovaná

Vydáno

2017

Stránek

220

EAN

9783330650909

ISBN

3330650907

Enbook ID

16123219

Vydavatel

SPS

Hmotnost

344

Rozměry

150 x 220 x 13

Kompletní popis

Mdm2 has been identified as a p53 interacting protein towards represses p53 transcriptional activity.Mdm2 achieves this repression by binding to P53 and blocking the N- terminal transactivation domain of p53. Mdm2 is a p53 responsive gene that is; its transcription can be activated by p53. When p53 is stabilized, the transcription of Mdm2 is also induced, resulting in higher mdm2 protein levels causing recognition and repair, transcription regulation problems leading to cancer. Thus inhibiting the mdm2- p53 interactions has been proven to be most promising approach for cancer therapy.

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