Kniha Nisin Based Lantibiotic Engineering V. Mohanasrinivasan

Nisin Based Lantibiotic Engineering

A novel approach on biopreservation

Jazyk: Angličtina
Vazba: Brožovaná
Dostupnost: U nakladatele na objednávku
Odesíláme za 17-27 dnů
1 174
Lantibiotics are ribosomally synthesized polycyclic peptide containing unusual amino acids, which ha...

Informace o knize

Jazyk
Angličtina
Vazba
Kniha - Brožovaná
Vydáno
2012
Stránek
80
EAN
9783659254734
Enbook ID
06956260
Hmotnost
123
Rozměry
150 x 220 x 4

Kompletní popis

Lantibiotics are ribosomally synthesized polycyclic peptide containing unusual amino acids, which have binding specificity for bacterial cells, targeting the bacterial cell wall component lipid II to form pores and there by lyses the cell. Nisin is the one of the most studied commonly used lantibiotics. Nisin inhibit the growth of bacteria by inhibiting cell wall synthesis via binding to Lipid II. Nisin have thio esters five ring system. But first three are actively involved in antimicrobial activity. These are binding to pyrophosphate moiety of lipid II. This mode of action is the rationale for design of small nisin derived peptide to obtain novel potential lantibiotics. As conformational constraints the Thioether Bridge was mimicked by alkanes or alkenes by ring closing metathesis.

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