Primary Progressive Multiple Sclerosis

Name: Primary Progressive Multiple Sclerosis
Brand: Springer Verlag
SKU: 9788847022362
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Autor: G. Comi, M. Filippi

Jazyk:

Vazba: Brožovaná

Vydavatel: Springer Verlag

Dostupnost: Skladem u dodavatele

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"Why are there no effective treatments for my condition? Why do researchers exclude patients with pr...

Informace o knize

Autor

G. Comi, M. Filippi

Jazyk

Angličtina

Vazba

Kniha - Brožovaná

Vydáno

2012

Stránek

128

EAN

9788847022362

ISBN

9788847022362

Enbook ID

06623906

Vydavatel

Springer Verlag

Hmotnost

226

Rozměry

155 x 235 x 8

Kompletní popis

"Why are there no effective treatments for my condition? Why do researchers exclude patients with primary progressive multiple sclerosis from enrolling in clinical trials? Please let me know if you hear of studies that I might be allowed to enter or treatments that I could try for my condition. " Thus, in recent years, the sad lament of the patient with primary progressive MS (PPMS). This variant, often in the guise of a chronic progressive myelopathy or, less commonly, progressive cerebellar or bulbar dysfunction, usually responds poorly to corticosteroids and rarely seems to benefit to a significant degree from intensive immunosuppressive treatments. In recent years, most randomized clin ical trials have excluded PPMS patients on two counts. Clinical worsening devel ops slowly in PPMS and may not be recognized during the course of a 2-or 3-year trial even in untreated control patients. This factor alone adds to the potential for a type 2 error or, at the very least, inflates the sample size and duration of the trial. In addition, there is mounting evidence that progressive axonal degeneration and neuronal loss (rather than active, recurrent inflammation) may be important components of the pathology in this form of the disease. Although contemporary trials are evaluating whether PPMS patients may benefit from treatment with the ~-interferons and glatiramer acetate, preliminary, uncontrolled clinical experi ence suggests that the results may not be dramatic.

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Primary Progressive Multiple Sclerosis

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