Kniha Proteins Gregor Anderluh

Proteins

Membrane Binding and Pore Formation

Jazyk: Angličtina
Vazba: Pevná
Dostupnost: Skladem u dodavatele
Odesíláme za 9-15 dnů
5 156
There are currently only two structures of pores available, of -toxin from Staphylococcus aureus and...

Informace o knize

Jazyk
Angličtina
Vazba
Kniha - Pevná
Vydáno
2010
Stránek
172
EAN
9781441963260
ISBN
144196326X
Enbook ID
01423957
Hmotnost
482
Rozměry
173 x 259 x 18

Kompletní popis

There are currently only two structures of pores available, of -toxin from Staphylococcus aureus and hemolysin E from Escherichia coli. So what we know about these proteins was obtained over many years of intense experimentation. We have nevertheless, in the last couple of years, witnessed a significant rise in structural information on the soluble forms of pore-forming proteins. Surprisingly, many unexpected similarities with other proteins were noted, despite extremely low or insignificant sequence similarity. It appears that lipid membrane binding and formation of transmembrane channels is achieved in many cases by a limited repertoire of structures. This book describes how several of the important pore forming toxin families achieve membrane binding and which structural elements are used for formation of transmembrane pores. Our contributors have thus provided the means for a comparative analysis of several unrelated families.

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