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BRICHOS Domain

Name: BRICHOS Domain
Brand: Springer International Publishing AG
SKU: 9783319165639
Price: 1310 CZK
Availability: InStock

Its Proproteins and Functions

Autor: Jenny Presto, Jan Johansson

Jazyk:

Vazba: Brožovaná

Vydavatel: Springer International Publishing AG

Dostupnost: Skladem u dodavatele v malém množství

Odesíláme za 13-18 dnů

1 310 Kč

This Brief summarizes the current research on the novel BRICHOS domain, which is a chaperone domain...

Informace o knize

Autor

Jenny Presto, Jan Johansson

Jazyk

Angličtina

Vazba

Kniha - Brožovaná

Vydáno

2015

Stránek

EAN

9783319165639

ISBN

3319165631

Enbook ID

09208432

Vydavatel

Springer International Publishing AG

Hmotnost

103

Rozměry

155 x 235 x 2

Kompletní popis

This Brief summarizes the current research on the novel BRICHOS domain, which is a chaperone domain found in a variety of proteins and is shown to exhibit anti-amyloidogenic chaperone-like functions. The BRICHOS domain is defined from sequence similarities, lacks established physiological function(s) and is found about 10 distantly related pro-protein families, several of which are associated with human disease. In this work, the authors review the mechanism by which BRICHOS inhibits A aggregation and examine recent results from in vivo experiments where BRICHOS inhibits A aggregation and toxicity in Drosophila melanogaster. BRICHOS is one of nature s (more specific) ways to protect against fibril formation, and exploring the potential of using the BRICHOS domain in the fight against Alzeimer's Disease and other amyloid diseases seems highly relevant. This brief is useful for newcomers to this field or researchers in related fields wishing to gain a quick overview of the latest findings.