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Vaccine Efficacy Evaluation

Name: Vaccine Efficacy Evaluation
Brand: Taylor & Francis Ltd
SKU: 9781032234748
Price: 3888 CZK
Availability: InStock

The Gnotobiotic Pig Model

Autor: Yuan, Lijuan (Department of Biomedical Sciences and Pathobiology, Virginia Tech, Blacksburg, Virginia, USA)

Jazyk:

Vazba: Pevná

Vydavatel: Taylor & Francis Ltd

Dostupnost: 50 % šance

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3 888 Kč

Testing the immunogenicity, protective efficacy and safety in animal models is a crucial step in vac...

Informace o knize

Autor

Yuan, Lijuan (Department of Biomedical Sciences and Pathobiology, Virginia Tech, Blacksburg, Virginia, USA)

Jazyk

Angličtina

Vazba

Kniha - Pevná

Vydáno

2022

Stránek

189

EAN

9781032234748

ISBN

1032234741

Enbook ID

37333208

Vydavatel

Taylor & Francis Ltd

Hmotnost

539

Kompletní popis

Testing the immunogenicity, protective efficacy and safety in animal models is a crucial step in vaccine development. Pigs raised in germ-free environments, called gnotobiotic (Gn) pigs, are one of the most useful animal models for testing vaccines. The Gn pig model is a widely accepted model for studying pathogenesis and immunity and an ideal model for pre-clinical testing for the safety and efficacy of enteric viral vaccines. Through these studies and others, the Gn pig model has been established as the most reliable animal model for pre-clinical evaluation of human rotavirus and norovirus vaccines. This book provides detailed information on establishing Gn pig models, determining a proper virus inoculum pool and challenge dose, measuring protection and calculating efficacy, and delineating intestinal and systemic immune responses associated with the protection.

Key Features

Provides a natural history of human rotavirus and norovirus infection in Gn pigs
Establishes the optimal virus challenge doses in Gn pigs for vaccine evaluation
Evaluates various candidate rotavirus and norovirus vaccines
Discusses human gut microbiota transplanted Gn pig models
Documents the role of probiotics and rice bran as prophylactics and vaccine adjuvants

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Vaccine Efficacy Evaluation

The Gnotobiotic Pig Model

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