Kniha Vaccines and Hypervariable Viruses Ali Azizi

Vaccines and Hypervariable Viruses

Design and Development of HIV-1, HCV, and SARS-CoV Candidate Vaccines

Autor: Ali Azizi
Jazyk: Angličtina
Vazba: Brožovaná
Vydavatel: VDM Verlag
Dostupnost: U nakladatele na objednávku
Odesíláme za 17-27 dnů
1 618
It is difficult to induce protective immunity against most RNA viruses. However, there is strong evi...

Informace o knize

Autor
Jazyk
Angličtina
Vazba
Kniha - Brožovaná
Vydáno
2009
Stránek
196
EAN
9783639049626
ISBN
3639049624
Enbook ID
06814482
Vydavatel
Hmotnost
295
Rozměry
152 x 229 x 11

Kompletní popis

It is difficult to induce protective immunity against most RNA viruses. However, there is strong evidence that humoral and especially cellular immune responses play crucial roles in the control of established RNA viral infections. Herein, correlates of protective immunity against HIV-1, HCV and SARS- CoV were assessed by various strategies. In the first study, we showed that a combination of monocistronic DNA constructs expressing HIV-1 structural genes, HIV-1 recombinant proteins and a potent adjuvant is able to induce humoral and cellular immune responses in HLA.A2.1 mice. In the second HIV-1 study, a synergistic effect between HIV- 1 and hepatitis C (HCV) immunogens was detected that may lead to induction of multi-specific immune responses against both HIV and HCV. In the third study, a high level of specific SARS-CD8+T-cell response was demonstrated in mice that received DNA vaccine expressing the SARS-nucleocapsid, protein and XIAP (X-link inhibitor of apoptosis) as an adjuvant.

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