VIP Protects Th2 Cells by Downregulating Granzyme B Expression

Name: VIP Protects Th2 Cells by Downregulating Granzyme B Expression
Brand: VDM Verlag
SKU: 9783836488259
Price: 1407 CZK
Availability: InStock

Autor: Vikas Sharma

Jazyk:

Vazba: Brožovaná

Vydavatel: VDM Verlag

Dostupnost: U nakladatele na objednávku

Odesíláme za 17-27 dnů

1 407 Kč

Following antigenic stimulation, CD4+ T cells§differentiate into Th1 and Th2 effectors, with§differe...

Informace o knize

Autor

Vikas Sharma

Jazyk

Angličtina

Vazba

Kniha - Brožovaná

Vydáno

2008

Stránek

132

EAN

9783836488259

ISBN

3836488256

Enbook ID

07089751

Vydavatel

VDM Verlag

Hmotnost

186

Rozměry

152 x 229 x 7

Kompletní popis

Following antigenic stimulation, CD4+ T cells§differentiate into Th1 and Th2 effectors, with§different cytokine profiles and different§physiological functions. However, regardless of the§initial Th1/Th2 balance, the final immune response§depends to a large degree on the regulation of Th1 or§Th2 survival under specific conditions. §The major purpose of this thesis was to identify and§characterize the molecular mechanisms for the§protective effect of VIP on Th2 effectors in an in§vitro system. Our experiments revealed a surprising§new mechanism involved in Th1/Th2 AICD, i.e. the§induction of enzymatically active granzyme B (GrB)§upon T cell receptor restimulation. In wild-type Th1§and Th2 cells, apoptosis is mediated through both Fas§signaling and GrB induction. In lpr (Fas mutant) Th1§and Th2 effectors T cell receptor restimulation§results in apoptosis mediated solely by GrB,§suggesting that GrB induction is independent of Fas§signaling. VIP induces the survival of wild-type Th2§effectors by preventing the induction of GrB and the§upregulation of FasL expression in Th2, but not Th1§cells.

Mohlo by vás zajímat

Zákaznicí kteří koupili tuto knihu koupili také

Nejčastěji hledané

Categories

Authors

Publishers

Produkty

Produkty

Nejčastěji hledané

Categories

Authors

Publishers

Produkty

Produkty

VIP Protects Th2 Cells by Downregulating Granzyme B Expression

Informace o knize

Kompletní popis

Mohlo by vás zajímat

Zákaznicí kteří koupili tuto knihu koupili také