Kniha Hypertension Jérôme P. Fennell

Hypertension

Methods and Protocols

Jazyk: Angličtina
Vazba: Pevná
Vydavatel: Humana Press Inc.
Dostupnost: Skladem u dodavatele v malém množství
Odesíláme za 13-18 dnů
3 937
Our understanding of the pathogenesis of hypertension and the development of new therapies for its m...

Informace o knize

Jazyk
Angličtina
Vazba
Kniha - Pevná
Vydáno
2004
Stránek
502
EAN
9781588293237
ISBN
1588293238
Enbook ID
01430349
Vydavatel
Hmotnost
1990
Rozměry
155 x 235 x 33

Kompletní popis

Our understanding of the pathogenesis of hypertension and the development of new therapies for its management have each proven to be directly dependent on the availability and application of novel molecular biological methodologies. In Hypertension: Methods and Protocols, a panel of recognized experts from key institutions around the world describes in step-by-step detail many new and essential molecular techniques for cardiovascular hypertension research. The methods presented range widely from producing congenic, consomic, transgenic, and knockout models of hypertension to the gene transfer of specific genetic material using adenoviral and nonviral (polymers, liposomes, and antisense agents) vectors. Additional techniques described include single nucleotide polymorphism (SNP) genotyping, RNA interference, microarray analysis, pharmacogenetics, and pharmacogenomics for the genetic dissection of hypertension, as well as a practical method for deriving cardiomyocytes from embryonic stem cells that would serve as replacement cells for those damaged by hypertension or heart attack. A review of bioinformatic resources for pharmacogenomics describes the application of in silico strategies to identify nuclear matrix attachment regions. The protocols follow the successful Methods in Molecular Medicine series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.§State-of-the-art and highly practical, Hypertension: Methods and Protocols offers both novice and experienced hypertension researchers an indispensable collection of readily reproducible techniques for successful research, work that has already dramatically improved the outlook for hypertensive patients, and promises much future success.

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