Kniha Lipid Rafts Dan Sillence

Lipid Rafts

Properties, Controversies & Roles in Signal Transduction

Autor: Dan Sillence
Jazyk: Angličtina
Vazba: Pevná
Dostupnost: 50 % šance
Prohledáme celý svět
5 420
For many years, the surface of cells was viewed as a homogeneous fluid lipid casing. However, it is...

Informace o knize

Autor
Jazyk
Angličtina
Vazba
Kniha - Pevná
Vydáno
2014
Stránek
225
EAN
9781629489612
ISBN
9781629489612
Enbook ID
06433684
Hmotnost
514
Rozměry
156 x 238 x 19

Kompletní popis

For many years, the surface of cells was viewed as a homogeneous fluid lipid casing. However, it is now understood that the surface of cells is not homogeneous but instead contains domains selectively enriched in particular lipids and proteins. Although it is still not completely clear how these lipid platforms are formed, their existence provides a basis for the organisation of many cell processes. One possibility is that microdomain formation relies on lipid phase separation in the plane of the bilayer -- ''lipid raft'' hypothesis. Lipid rafts are compelling since they provide spontaneous organisation for signal transduction as well as intracellular sorting and targeting. What are the functions of these domains? Do they rely on specific interactions and how do they change in response to cell signalling processes? Do they help in the understanding of cell signalling and immune function and how may they be disrupted in disease processes such as neurodegeneration?

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